Chronic Kidney Disease Vitamin D Deficiency. One aspect of chronic kidney disease ckd is unquestioned. Vitamin d deficiency 20 ng ml and insufficiency 20 29 ng ml are common among patients with chronic kidney disease ckd or undergoing dialysis.
Vitamin d has a number of pleiotropic effects in a variety of tissues in addition to its well known effects on mineral metabolism. Chronic kidney disease ckd has been recognized as a significant global health problem because of the increased risk of total and cardiovascular morbidity and mortality. Whether it is early renal impairment or once end stage disease ensues vitamin d concentrations are inadequate to maintain optimal mineral balance.
In addition to nutritional and sunlight exposure deficits factors that affect vitamin d deficiency include race sex age obesity and impaired vitamin d synthesis and metabolism.
The benefits and harms of vitamin d supplementation ergocalciferol or cholecalciferol were assessed in patients with nondialysis dependent ckd dialysis dependent ckd and renal transplant recipients. In healthy subjects vitamin d s role in disease prevention runs the gamut of cancer to diabetes with only bone health firmly established. We measured the concentrations of 25 hydroxyvitamin d 25d 1 25. Because active vitamin d therapy cannot correct vitamin d deficiency which correlates with proteinuria 50 and higher risk for hypertension 51 insulin resistance 52 cardiovascular disease 53 in individuals with normal serum 1 25 dihydroxyvitamin d and normal kidney function a currently unresolved issue is whether 25 hydroxyvitamin d levels should also be raised to ensure the benefits of.