Kidney Conversion Of Vitamin D. 1 you may think that is a good thing but without the hormones in place to deposit the calcium and phosphate into the bones the calcium and phosphate deposit into soft tissues. It accumulates very rapidly in the liver where it undergoes 25 hydroxylation yielding 25 oh d3 the major circulating metabolite of the vitamin.
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With chronic kidney disease low vitamin d levels can be found sometimes even severely low levels. It accumulates very rapidly in the liver where it undergoes 25 hydroxylation yielding 25 oh d3 the major circulating metabolite of the vitamin. As 1 25 dihydroxy vitamin d synthesis is substrate dependent in end stage renal disease this could be a contributing factor to low 1 25 dihydroxy vitamin d levels in patients undergoing conventional hemodialysis.
There has been much progress in our understanding of the metabolism of vitamin d.
It is now clear that vitamin d3 can be produced in the skin or ingested in the diet. With chronic kidney disease low vitamin d levels can be found sometimes even severely low levels. In humans the most important compounds in this group are vitamin d 3 also known as cholecalciferol and vitamin d 2 ergocalciferol. Patients on conventional hemodialysis have low levels of 25 hydroxy vitamin d probably due to diet and decreased cutaneous synthesis.
