Kidney Regeneration Approaches For Translation. This review will discuss the fundamental concepts of transcription factor based reprogramming in its various forms highlighting recent advances in the field and how these are applicable to the kidney. 2 department of urology soonchunhyang university college of medicine cheonan south korea.
We expect that the insights gained from these studies will facilitate the translation of de novo nephrogenesis to human nephron cultures and as a result the development of new approaches to study and treat kidney disease. The devastating effects of esrd along with the increasing demand for renal transplantation and the critical shortage of donor organs has accelerated the search for alternative treatment modalities. Tissue engineering and regenerative medicine approaches have been applied in recent years to develop viable therapies that could provide solutions to these patients.
We propose that harmonized rigorous protocols for characterization handling and delivery of stem cells in vivo could significantly advance the field and present details of some suggested approaches to foster translation in the field of renal regeneration.
Recent findings recent progress in regenerative nephrology includes the directed differentiation of embryonic stem cells to kidney fates understanding the proliferative capacity of tubules after injury the use of mesenchymal stem cells for kidney disease and tissue engineering approaches to renal replacement. Tissue engineering and regenerative medicine approaches have been applied in recent years to develop viable therapies that could provide solutions to these patients. We expect that the insights gained from these studies will facilitate the translation of de novo nephrogenesis to human nephron cultures and as a result the development of new approaches to study and treat kidney disease. We highlight a variety of stem cell approaches in preclinical development for acute kidney injury aki and chronic kidney disease ckd.