Kidney Renal Oxygen Consumption. The goal of this review is to discuss the alterations in renal oxygenation delivery consumption and tissue oxygen tension in pre clinical and clinical studies in diabetic and hypertensive ckd along with the underlying mechanisms and potential therapeutic options. E renal oxygenation is impaired and vice versa.
Oxygen Delivery Oxygen Consumption And Decreased Kidney Function After Cardiopulmonary Bypass from journals.plos.org
Because sodium handling plays an essential role in renal energy and oxygen requirements it has been thought that a change in sodium intake could have a beneficial influence on oxygenation status. Intrarenal microcirculation was not changed but deoxyhemoglobin signals rose in diabetic kidney and oxygen consumption by tubular cells was significantly enhanced palm et al 2003. Requested normotensive and hypertensive nondiabetic young men to adhere to a 1 week low sodium diet and a 1 week high sodium.
Renal oxygenation is defined as the relationship between renal oxygen delivery do 2 and renal oxygen consumption vo 2 and it can easily be shown that the inverse of this relationship is equivalent to renal extraction of o 2 o 2 ex.
Because sodium handling plays an essential role in renal energy and oxygen requirements it has been thought that a change in sodium intake could have a beneficial influence on oxygenation status. The goal of this review is to discuss the alterations in renal oxygenation delivery consumption and tissue oxygen tension in pre clinical and clinical studies in diabetic and hypertensive ckd along with the underlying mechanisms and potential therapeutic options. Therefore pruijm et al. The kidney since the parallel increase in gfr which ac companies rbf will also augment reabsorption and con sequently the adenosine triphosphate atp and oxygen required 9 10.