Kidney Stone Formation Model. An experimental method of calcium containing renal stone formation was devised using a rabbit on normal diet. Kidney stone disease is a crystal concretion formed usually within the kidneys.
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Thus there are many similarities between experimental nephrolithiasis induced in rats and human kidney stone formation and a rat model of calcium oxalate nephrolithiasis can be used to investigate the mechanisms involved in human kidney stone formation. Stone formation is the last stage in a long process starting with development of supersaturation followed by nucleation growth aggregation and retention of crystals within the kidneys. Kidney stone disease is a crystal concretion formed usually within the kidneys.
The stones are made of mineral and acid salts.
Three pathways of stone formation and growth. Supersaturation of the urine with calcium and oxalate salts followed by crystalline particle formation is the major reason behind kidney stone formation with supersaturation being the driving force. It is an increasing urological disorder of human health affecting about 12 of the world population. The problem of kidney stone disease 10.
