Renal Regeneration After Acute Kidney Injury. Cellular and molecular pathways of renal repair after acute kidney injury sanjeev kumar1 1board of governors regenerative medicine institute cedars sinai medical center los angeles california usa the acutely injured mammalian kidney mounts a cellular and molecular response to repair itself. After injury ptec regeneration leads to the restoration of epithelial morphology and kidney function however particularly in regions of persistent or severe injury the regenerative processes are frequently inefficient impaired and dysregulated resulting in extensive tissue remodeling and fibrosis.
The capacity of the kidney to regenerate functional tissue after an episode of acute injury is a major determinant of outcome for patients with acute kidney injury. The gdf11 expression pattern and its effect on organ regeneration after acute injury in the elderly population are highly controversial topics. Acute kidney injury aki is a frequent complication of critical illness and carries a significant risk of short and long term mortality chronic kidney disease ckd and cardiovascular events.
Cellular and molecular pathways of renal repair after acute kidney injury sanjeev kumar1 1board of governors regenerative medicine institute cedars sinai medical center los angeles california usa the acutely injured mammalian kidney mounts a cellular and molecular response to repair itself.
No specific therapy improves the rate or effectiveness of the repair process after acute renal injury. Acute kidney injury is common and associated with negative renal and patient outcomes. Understanding renal regeneration may allow us to manipulate this process and thus develop therapeutic weapons to improve patients outcome. Renal regeneration process after acute kidney injury aki caused by ischemic or toxic conditions leads to renal dysfunction and loss of tubular epithelial cells.