Vitamin D Metabolism In Chronic Kidney Disease. Improved glucose metabolism is one potential mechanism through which vitamin d may exert beneficial effects. Vitamin d therapy holds promise for improving health outcomes in chronic kidney disease.
Vitamin d deficiency or insufficiency is common in patients with ckd and serum levels of vitamin d appear to have an inverse correlation with kidney function. However further data from clinical trials are needed to test whether vitamin d has clinically relevant long term effects on glucose metabolism and overall clinical outcomes. The gradual and progressive decline in 1 25 dihydroxyvitamin d in the course of chronic kidney disease is the result of several mechanisms that limit the ability of the failing kidney to maintain the levels of 1 25 dihydroxyvitamin d despite increasing levels of parathyroid hormone.
Improved glucose metabolism is one potential mechanism through which vitamin d may exert beneficial effects.
However further data from clinical trials are needed to test whether vitamin d has clinically relevant long term effects on glucose metabolism and overall clinical outcomes. Vitamin d therapy holds promise for improving health outcomes in chronic kidney disease. To determine whether or not chronic kidney disease ckd stages iii v and esrd is associated with altered vitamin d metabolism related to fibroblast growth factor 23 fgf 23 stimulation of cyp24 and whether they have resistance to elevations of 25 hydroxyvitamin d 25 oh d3 after cholecalciferol supplementation. Improved glucose metabolism is one potential mechanism through which vitamin d may exert beneficial effects.